My sister in law is one of my favorite people. I absolutely adore her. She has always had a bit of a weight problem, but no big deal (I have too). But over the past 10 years, it has gotten much, much worse. I just saw her last weekend, and she is easily over 400 pounds right now. She is wildly successful professionally and still works, manages kids, etc, but you can tell she's really struggling. She's losing mobility. We also both turned 50 this year and not getting any younger. I would never say anything, because it's not like she doesn't already know. And nothing I say will do anything other than make her feel worse. But I am so, so worried about her. I don't want to lose her, but I really don't think she'll be around in 10 years if something doesn't change. It makes me sad.